Iambic Therapeutics

Iambic Therapeutics, Inc. is a technology and clinical-stage life sciences company. Its molecular superintelligence platform integrates proprietary AI technologies with automated, scalable chemistry and biology experimentation. Its pipeline of drug candidates is developed using a molecular superintelligence platform. IAM1363, is a HER2 inhibitor that is in a Phase I/Ib clinical trial in subjects with HER2-altered solid tumors. The Company's additional programs, IAM217 (KIF18A inhibitor) and IAM-C1 (dual CDK2/4 inhibitor), are in preclinical development. IAM1363 is an oral, selective, pan-mutant, and brain-penetrant small molecule inhibitor that selectively targets HER2 and HER2 mutants, while sparing EGFR. Amplification and mutations of HER2 drive a wide range of human cancers. IAM-C1 is a small-molecule inhibitor with a differentiated selectivity profile, designed to specifically target CDK2 and CDK4, two cell-cycle kinases that are frequently dysregulated in various cancers.